SAMe S Adenosyl Methionine was first discovered in 1952 and has been commercially available in Europe since the 1970's. SAMe is an important compound that occurs in every living cell and takes part in several biological reactions in the human body. The important physiological results of these reactions are the manufacture of joint cartilage and the maintenance of neural cell membrane function. SAMe has been studied extensively and has been clinically found to promote and support Joint Health, Mobility and Joint Comfort Mood and Emotional Well being The Inside Scoop S Adenosyl Methionine Nutrition Facts Serving Size tabs 2 Servings Per 10 SAMe mg 200 Suggested Use For optimal absorption into the body, the best time to take SAMe is on an empty stomach at least 30 minutes before a meal. To support and promote joint health, mobility and joint comfort, take 2 tablets twice a day. Clinical studies indicate that benefits may be evident in the first two weeks of suppl